When MSD was established, its procurement, storage and distribution of health products were carried out without the use of IT systems where employees used special papers used to order and store records of health products such as Bin Card, Combined Requisition and Issue note (CRIN). In 1998, the use of IT began to be used to enhance the performance of its functions in the area of financial management using a system called Navision Financials.

In addition, in 2001, a feasibility study was conducted on the performance and operation of MSD activities and thus the Orion ERP system was officially established at the headquarters in Dar es Salaam and connected all Zones through the TTCL network in 2002. This system was used to carry out procurement, storage, distribution and financial management activities. In 2012, MSD made a system change from Orion ERP and introduced the Epicor9 ERP system which was using the most modern technology to improve its services due to the growth of the Institute's activities. This continued to improve the use of IT through funding from USAID and Global Fund partners.

From July 2020, MSD began using the Epicor10 system which is an improvement on the previous Epicor9 system. Due to the growing demand in implementing healthcare supply chain functions, MSD is in the final stages of building a new ERP system.

Other systems include;

• MSD Portal and POD - A customer service system to access various information and services within the supply chain system.

Visitors System - Manages visitors entering all MSD offices

e-Office - Manages the Government Electronic System

eSSPS - A system that facilitates the procurement of healthcare products within SADC countries.

GePG - Manages government payments.

Fleet Management - This system is used in the management of the transportation system

Bank Integration - Integrating banking systems to reduce human errors during payments.

Wambo and other Systems Integration MSD - has continued to enable various systems to talk. MSD has been working to improve its operations by integrating with various systems such as WAMBO, E10-MoF, eLMIS, GoTHoMIS and the Ministry of Health facility management system.

Digitization Platform - A platform for integrating employee activities within the warehouse digitally. The successful implementation of this work will ensure MSD's commitment towards working without paper.

ESS - A self-service system for employees to access various internal information and services (Salary Information, Apply for Loans (Salary Advance Loan), Vacation

Digital Signature - An electronic digital signature system developed by the e-Government Authority (e-GA) to increase trust in digital communication in government, simplify processes by reducing the need for paper signatures.

NeST - A public procurement system managed by PPRA

Dashboard - A system to help decision makers and executives access various information in the supply chain.